Sigma-Aldrich Valproic Acid sodium Salt

2-propylpentanoic acid sodium; Sodium 2-propylpentanoate; Sodium valproate. Valproic acid sodium salt has been used: in resazurin viability assayto systematically study its effects of clinical doses on brain volume and offspring behaviorto study its effect on atherosclerotic ...2-propylpentanoic acid sodium; Sodium 2-propylpentanoate; Sodium valproate. Valproic acid sodium salt has been used: in resazurin viability assayto systematically study its effects of clinical doses on brain volume and offspring behaviorto study its effect on atherosclerotic lesion sizein genetic expression studies in mice This compound is a featured product for Neuroscience research.

The antiepileptic effects of Valproic acid (VPA) are achieved by reducing high-frequency neuronal firing through the blockage of voltage-gated sodium, potassium, and calcium channels. This medication affects the biochemical occurrence of aura and impacts pain perception by modulating GABA or glutamate-mediated neurotransmission. Additionally, VPA influences signaling systems such as the Wnt/beta-catenin and ERK pathways, interfering with inositol and arachidonate metabolism.

Furthermore, VPA is crucial in expressing multiple genes involved in cell survival, transcription regulation, ion homeostasis, signaltransduction, and cytoskeletal modifications. Both immediate biochemical effects and long-term genomic influences explain the underlying effect of VPA in treating various conditions. Valproic acid is an anticonvulsant and mood-stabilizing drug.

It is used to treat epilepsy and bipolar disorder. Valproic acid helps to repress the Warburg effect and the development of tumor in neuroblastoma.